Edward married Amy Florence Sampson on 22 Oct 1917 in Port Pirie, , South Australia, Australia. Amy (daughter of William Sampson and Lavina Reed) was born on 26 Dec 1897 in Broken Hill, , New South Wales, Australia; and died. [Group Sheet] [Family Chart]

1. Helena Mary O'Brien was born on 18 Apr 1918 in Solomontown, , South Australia, Australia; and died.
2. Leslie James O'Brien was born on 28 Sep 1919 in Port Pirie, , South Australia, Australia; died on 8 Feb 1920 in Port Pirie, , South Australia, Australia.
3. Edward James O'Brien was born on 2 Jun 1921 in Port Pirie, , South Australia, Australia; and died.